Pleurotus citrinopileatus Extract Ergothioneine Powder

Product Description

What Is Ergothioneine？

Ergothioneine, also known as EGT or L-Ergothioneine,is an amino acid that is obtained from the diet. It is produced by certain types of bacteria and fungi; for example, mushrooms are a major dietary source of ergothioneine. Observational studies show that blood levels of ergothioneine tend to decrease with age, especially in individuals with physical and/or cognitive decline. Preclinical studies suggest that ergothioneine protects cells through antioxidant and anti-inflammatory properties. Ergothioneine is generally recognized as safe.

Ergothioneine powder can be used in innovative cosmetic formulations and scientifically formulated dietary supplements because it is derived from natural mushrooms, its stability has been proven, and it offers a variety of health benefits.

In 2017, the European Union approved ergothioneine as a Novel Food, confirming its safety for human consumption. Since humans and animals cannot synthesize ergothioneine internally, it must be obtained through diet (e.g., mushrooms, black beans, oats) or supplementation. Ergothioneine’s ability to neutralize free radicals, reduce UV-induced damage, and support collagen production makes it a sought-after ingredient in anti-aging serums, creams, and sun care products. Research suggests ergothioneine may support cognitive function, reduce inflammation, and protect against age-related cellular damage, driving demand in nutraceuticals and wellness supplements.

What is L-ergothioneine?

L-ergothioneine (L-EGT) is the levorotatory isomer of ergothioneine, belonging to the class of natural chiral amino acid compounds. It is the naturally occurring bioactive form of ergothioneine.

L-ergothioneine is naturally found in fungi (such as mushrooms and black truffles), some animal tissues, and grains. It can enter the mitochondria and nucleus via specific transport proteins on the cell membrane, directly scavenging free radicals and protecting genetic material.

Pleurotus citrinopileatus Extract Ergothionine Specification

What Are The Benefits of Ergothioneine?

1. Antioxidant Powerhouse
When we say ergothioneine is a “powerful antioxidant,” we highlight its exceptional ability to combat oxidative stress, a condition where harmful free radicals outnumber the body’s ability to neutralize them .

Free radicals are unstable molecules that can damage cells, proteins, and DNA. With its unique molecular structure, ergothioneine efficiently scavenges these radicals, stabilizing them and preventing cellular damage.

This action is key for maintaining cellular health and resilience, especially in organs that are highly susceptible to oxidative stress, such as the heart, brain, and liver.

By safeguarding cells in this way, we can see how ergothioneine supports overall well-being and health.

2. Healthy Aging Appearance
Ergothioneine’s role in promoting healthy aging extends beyond cellular protection, including potential benefits for looking younger.

As an antioxidant, ergothioneine taken internally or as part of skincare may help to shield the skin from environmental stressors like UV radiation and pollution, which accelerates aging signs .

By mitigating these effects, ergothioneine could aid in maintaining the skin’s elasticity and reducing the appearance of wrinkles and fine lines.

On top of this, ergothioneine modulates proinflammatory cytokines, which means it helps control substances that cause inflammation. When ergothioneine controls those overactive cytokines, it may help calm inflammation in the skin.

3. Cellular Protection
Ergothioneine’s ability to protect cells from environmental stresses is rooted in its unique physicochemical properties as a thio-histidine betaine amino acid.

As a thiol compound, it has a sulfur atom, which influences its antioxidant activity. This allows it to neutralize harmful substances effectively, like reactive oxygen species (ROS).

Ergothioneine is particularly adept at stabilizing these ROS, preventing them from causing cellular damage. Its unique molecular structure enables it to be effectively transported and concentrated in cells and tissues that are most vulnerable to oxidative stress, such as the liver and eyes [1].

By doing so, ergothioneine helps maintain cellular integrity and function in these critical areas, shielding them from environmental and oxidative challenges.

4. Cognitive Health

One clinical trial involving 92 healthy adults aged between 40 and 75 years observed the potential sleep and cognitive benefits of ergothioneine supplementation. Researchers found that incorporating ergothioneine supported brain health in adults .

Moreover, in research focusing on dementia, scientists have found that blood levels of ergothioneine are often low in patients with mild cognitive impairment and dementia.

This observation points towards the possible role of ergothioneine in maintaining cognitive function and suggests that it might be beneficial in managing or even preventing cognitive decline. However, before we get too excited about this, more research is needed to fully understand how ergothioneine treatment can impact cognitive health and its potential role in conditions like dementia.

5. Anti-Inflammatory Properties
Some research indicates that l-ergothioneine modulates tumor necrosis factor α (TNF-alpha), a critical component in the body’s inflammatory response. TNF-alpha is important for controlling inflammation, but too much can cause problems.

The study found that the diet-derived antioxidant ergothioneine helps calm down TNF-alpha activity.

When cells were exposed to stress and TNF-alpha, ergothioneine stepped in to reduce the activation of NF-kappa B, another component that turns on inflammation and lowers the release of IL-8, a chemical that signals more inflammation [9].

This shows us that l-ergothioneine’s anti-inflammatory properties could potentially provide therapeutic benefits in conditions characterized by chronic inflammation.

Ergothionine Dietary Sources

The primary dietary sources of Ergothionine are fungi. Nutriomics studies demonstrate that mushrooms contain significantly higher concentrations of EGT than any other human-palatable food group.

However, Ergothionine content in mushrooms varies widely among species. For example, specialty mushrooms such as oyster (Pleurotus ostreatus), shiitake (Lentinula edodes), maitake (Grifola frondosa), and lion’s mane (Hericium erinaceus) generally contain higher levels than white button mushrooms (Agaricus bisporus).

Although mushrooms are the most concentrated sources of Ergothionine, trace amounts of Ergothionine have been reported in beans, oats, and organ meats such as kidney and liver. This bioaccumulation of Ergothionine in these products occurs from plants and animals acquiring Ergothionine from fungi and bacteria present in the soil and their environment.

Ergothioneine Applications

• Dietary Supplements

Ergothioneine is widely used in dietary supplements as a “longevity vitamin” to improve energy, sleep, cognitive function, and overall anti-aging. It is often used in combination with other nutritional supplements (such as Coenzyme Q10, resveratrol, or vitamins) for synergistic effects.

• Cosmetics and Personal Care

Ergothioneine effectively eliminates UV-induced free radicals, thus delaying wrinkles and sagging skin, making it a core ingredient in high-end anti-aging skincare products. It is listed in the cosmetic ingredient lists of several countries and used in products such as serums, creams, and sunscreens.

• Beverages

As a powerful natural antioxidant, ergothioneine is added to beverages to develop new drinks with functions such as delaying aging, improving cognition, and supporting cardiovascular health, meeting consumer demand for healthy beverages. It has obtained GRAS certification from the EU and the US FDA, allowing its addition to beverages, cereal bars, and other common food products.

• Food and Agriculture

Ergothioneine can be used as a natural food additive to prevent blackening in seafood (such as shrimp and crab), extending its shelf life. Furthermore, its antioxidant and stress-resistance properties also give it potential in agriculture, such as as a plant protectant or to enhance crop resistance.

Why Our Ergothioneine Powder?

Our ergothioneine 99% powder is sourced from Pleurotus citrinopileatus Singer. It is produced through carefully controlled extraction and purification processes, guaranteeing high purity without synthetic additives. Due to its natural origin, our powder is efficiently absorbed and retained in human tissues, particularly in cells exposed to high oxidative stress (e.g., skin, liver, and eyes). Unlike some antioxidants that degrade easily, L-ergothioneine 99% powder remains stable under heat, light, and certain pH levels, making it ideal for formulations in supplements, cosmetics, and functional foods. The powder’s optimal particle size ensures excellent fluidity, facilitating easy handling and incorporation into various product formulations.

We offer OEM solutions, providing customized ergothioneine dosage forms such as capsules, tablets, and gummies. Clients can customize packaging and labeling to their needs, allowing your product to stand out in a competitive market. We combine in-house extraction technology with scalable production capacity to provide you with high-quality, ready-to-use raw materials, simplifying your product development process.

Market prospects and product applications

Ergothioneine is suitable for use in soft capsules, tablets, powders, and soft candies. Due to its antioxidant and cell protection effects, it can also be integrated into beauty and skin care products. The Nue Co. has developed Ergothioneine Gummies containing Ergothioneine as part of their supplement line, offering antioxidant and cellular protection benefits.

Currently, Ergothioneine is popular in the United States, Japan and European countries, especially in the fields of anti-aging and immune support.

Ergothioneine has strong antioxidant and anti-inflammatory properties, and has significant effects on anti-aging and supporting the immune system. The demand for it is increasing worldwide. Especially in the fields of anti-aging, immune support and skin care, Ergothioneine is considered a potential ingredient. According to a report by market research company Grand View Research, the global antioxidant market is expected to continue to grow, which provides a broad market opportunity for emerging ingredients such as Ergothioneine.

Ergothioneine Powder Quality Supplier And Manufacturer

Green Spring Bio is a professional supplier of plant extracts and active ingredients, dedicated to the research, development, production, and sales of plant active ingredients. With over 26 years of experience in supplying plant extracts, guaranteeing you a high quality product with competitive price, best service!! The company owns a cooperative factory covering over 1000 acres. Its products encompass over 1000 herbal extract, exported to 80% of countries and regions worldwide, serving over 1000 clients across various industries in more than 200 countries and regions,with annual exports exceeding 3000 tons.

We provide various dosage forms and neutral packaging including mixed powders, granules, soft capsules, hard capsules, tablets, soft candies, etc. to meet the different needs of customers.These active ingredients can be used in dietary supplements, cosmetics and personal care, health foods, functional foods and beverages,Animal and pet nutrition etc.

As a professional plant extract Active ingredients supplier,we have successfully obtained EU&NOP ,USDA, Kosher, Halal, ISO9001, BRC, FDA, COSMOS, IFS and other quality system certifications.

How To Buy Ergothioneine Powder Powder?

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