Product Name:Alpha Lipoic Acid/R-Alpha Lipoic Acid Powder
CAS No.:1077-28-7
Specification:99% Purity
Grade:Food Grade
Appearance:Pale yellow to yellow powder
Test Method:HPLC
Sample:10-50g Sample For free
MOQ:1kg
Quality:Non-GMO, Non-irradiation, Allergen Free, BSE/TSE Free
OEM Service: Private label and customized packaging available,OEM customized capsules
Certificate:ISO22000, FDA,BRC,COSMOS,IFS,SGS,Kosher, Halal, Organic(EU), USDA, HACCP, ISO9001
Alpha-lipoic acid (ALA) is a key organic compound produced naturally in human mitochondria, the “powerhouses” of cells, where it acts as a coenzyme to help turn nutrients into energy via aerobic metabolism.
What makes Alpha-lipoic acid unique is its dual solubility: unlike most antioxidants such as vitamin C (only water‑soluble) or vitamin E (only fat‑soluble), Alpha-lipoic acid dissolves in both water and fat, allowing it to work in every cell and tissue in the body. As a powerful antioxidant, it neutralizes harmful free radicals that damage cells, which is why it is often called the “universal antioxidant.”
These properties support several health benefits, including balanced blood sugar levels, reduced inflammation, delayed skin aging, and improved nerve function. The human body makes only small amounts of Alpha-lipoic acid, mainly in the liver, so additional intake from food or supplements is common. Rich dietary sources include red meat, organ meats, broccoli, tomatoes, spinach, and Brussels sprouts, while supplements can provide up to 1,000 times more Alpha-lipoic acid than natural food sources.
Alpha-lipoic acid has two enantiomers: R‑lipoic acid and S‑lipoic acid. The natural, biologically active form is R‑lipoic acid, which the body can use efficiently. Synthetic racemic lipoic acid has only about half the biological activity, since S‑lipoic acid is mostly inactive.
| Product Name | Alpha Lipoic Acid/R-Alpha Lipoic Acid Powder |
| Grade | Food Grade |
| CAS No. | 1077-28-7 |
| Specification | 99% Purity |
| Appearance | Pale yellow to yellow powder |
| Test Method | HPLC |
| COA | Avaialble |
| Certificate | ISO22000, FDA,BRC,COSMOS,IFS,SGS,Kosher, Halal, Organic(EU), USDA, HACCP, ISO9001 |
| Quality | Non-GMO, Non-irradiation, Allergen Free, BSE/TSE Free |
| Sample | 10-50g Sample For free |
| MOQ | 1kg |
| OEM Service | Private label and Customized package, |
| Packaging | Resealable bag, heat and light resistant,1kg/bag,25kg/50kgDrum |
| Shelf life | 2 year.Available for bulk wholesale, Individually packaged. |
| Note: Raw Material for production, not for personal sale. | |
Alpha-lipoic acid enhances skin elasticity, reduces fine lines and fights free radicals to delay skin aging by inhibiting glycation. It also regulates glucose metabolism and serves as a key antioxidant ingredient in cosmetics.
Alpha lipoic acid is an ingredient in many skin care products. In several small studies, ALA has been shown to reduce water loss from the skin and improve skin hydration, skin scaling, and roughness.
As an antioxidant, Alpha lipoic acid may help protect against skin damage by protecting against the sun’s harmful UV radiation and reducing fine lines, wrinkles, and age spots.
Alpha lipoic acid supplements may support mild weight loss by suppressing AMPK enzyme activity, reducing appetite and increasing calorie burn. A 2017 meta-analysis showed modest weight reduction compared to placebo, though optimal dosage requires further study.
A 2023 review of 11 studies revealed that Alpha lipoic acid supplementation (under 800 mg daily for up to 12 weeks) helps lower both systolic and diastolic blood pressure.
Alpha lipoic acid may help reduce total cholesterol, LDL (bad cholesterol), and triglycerides. Research varies across populations, with daily doses of 300–1,200 mg for 2–16 weeks.
Studies suggest Alpha lipoic acid can lower fasting blood glucose and HbA1c, though effects are inconsistent. Some reviews note mild improvements in people with type 2 diabetes.
R-ALA (R-alpha-lipoic acid) and ALA (alpha-lipoic acid) are closely related but not identical. Here’s a breakdown of their relationship and differences:
Alpha-Lipoic Acid (ALA). ALA is a naturally occurring compound that acts as an antioxidant. It is present in every cell of the body and helps turn glucose into energy. ALA exists in two forms (isomers), R-ALA (R-α-lipoic acid) and S-ALA (S-α-lipoic acid). When you take a standard ALA supplement, it typically contains a 50/50 mixture of R-ALA and S-ALA.
R-Alpha-Lipoic Acid (R-ALA). R-ALA is the biologically active form of ALA. It is the form that is naturally synthesized in the body and is responsible for most of the beneficial effects of ALA. R-ALA is considered to be more potent and bioavailable compared to the S-ALA isomer.
To sum it up, R-ALA is a specific, naturally occurring form of alpha-lipoic acid (ALA) that is more bioavailable and potent compared to its counterpart, S-ALA.
While they share similar properties, R-ALA is considered more potent and effective due to its higher bioavailability and efficacy.
| Feature | Alpha Lipoic Acid (ALA) | R-Alpha Lipoic Acid (R-ALA) |
| Composition | A 50/50 mixture of R- and S-forms. | The single, naturally occurring, and biologically active R-form. |
| Bioavailability | Lower, as the S-form is less bioavailable. | Higher, as it is the active form the body naturally uses. |
| Potency | Less potent, as it contains 50% of the active R-form and 50% of the less active S-form. | More potent, as it is the pure, active form. |
| Primary Use | A common, less expensive supplement that provides a mix of R and S forms. | Often recommended for a more direct and effective dose of the biologically active component. |
| Effectiveness | Provides some benefits from the R-form, but the S-form contributes little to the beneficial effects. | Demonstrates superior antioxidant effects and is more effective in supporting cellular metabolism and other benefits associated with ALA. |
1.Superior Antioxidant & Metabolic Support
Dual Solubility: Unique water- and fat-soluble properties enable systemic protection, including crossing the blood-brain barrier.
Regenerates Antioxidants: Recycles vitamin C, glutathione, and coenzyme Q10, enhancing cellular defense against oxidative stress.
Clinically Proven Benefits: Reduces diabetic neuropathy symptoms by 68% and improves insulin sensitivity.
2.High Bioavailability & Purity
Natural R-Alpha Lipoic Acid Powder: ≥99% purity via low-temperature fermentation, offering 10x higher bioactivity than synthetic S-ALA.
Zero Additives: Heavy metals <1 ppm, microbial limits <1,000 CFU/g (USP-compliant).
3.Multifunctional Applications
Pharmaceuticals: Used in diabetic neuropathy, Alzheimer’s disease, and chemotherapy-induced liver protection.
Cosmetics: Anti-aging formulations for UV protection and collagen synthesis.
Green Spring is a professional cosmetic ingredient supplier with a dedicated R&D team focused on discovering, refining, and testing the various components needed for finished cosmetic products. The company boasts an independent R&D center that meets international standards and has a team with 26 years of R&D experience.
We offer a wide variety of active and functional cosmetic ingredients, all of which have undergone rigorous scientific testing to verify their efficacy and ensure purity and effectiveness, helping companies build brands and develop market strategies.
As a professional Alpha lipoic acid Powder manufacturer and cosmetic ingredient supplier, we provide high-purity Alpha lipoic acid Powder/R-Alpha lipoic acid Powder.
Fully compliant with global regulations (FDA 21 CFR §182.3619, EU No 1170/2010, USP 47), our alpha lipoic acid powder is free of GMOs, heavy metals (Pb≤0.1ppm), and artificial additives. It holds USDA Organic, Kosher, and Vegan certifications, perfectly aligning with “clean label” and “natural active” trends. Trusted by 280+ global brands (including Nature’s Bounty and La Roche-Posay), we provide full traceability via QR code-tracking from raw material sourcing to finished powder-to ensure regulatory peace of mind for clients in Europe, America, and Japan..
Just send an email to sales@greenspringbio.com, or submit your needs in the form at the bottom, we are always at your service!
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